Correctly validating results from single molecule data: the case of stretched exponential decay in the catalytic activity of single lipase B molecules

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dc.creatorFlomenbom, Ophir
dc.creatorHofkens, Johan
dc.creatorVelonia, Kelly
dc.creatorde Schryver, Frans C.
dc.creatorRowan, Alan E.
dc.creatorNolte, Roeland J. M.
dc.creatorKlafter, Joseph
dc.creatorSilbey, Robert J.
dc.date2007-02-22
dc.date.accessioned2026-07-07T07:48:16Z
dc.date.available2026-07-07T07:48:16Z
dc.descriptionThe question of how to validate and interpret correctly the waiting time probability density functions (WT-PDFs) from single molecule data is addressed. It is shown by simulation that when a stretched exponential WT-PDF, with a stretched exponent alfa and a time scale parameter tau, generates the off periods of a two-state trajectory, a reliable recovery of the input WT-PDF from the trajectory is obtained even when the bin size used to define the trajectory, dt, is much larger than the parameter tau. This holds true as long as the first moment of the WT-PDF is much larger than dt. Our results validate the results in an earlier study of the activity of single Lipase B molecules and disprove recent related critique.
dc.identifierhttps://arxiv.org/abs/q-bio/0702045
dc.identifierhttp://arxiv.org/abs/q-bio/0702045
dc.identifierChem. Phys. Lett. 432, 371-374 (2006)
dc.identifierdoi:10.1016/j.cplett.2006.10.060
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/124435
dc.subjectSubcellular Processes
dc.subjectSoft Condensed Matter
dc.subjectBiomolecules
dc.titleCorrectly validating results from single molecule data: the case of stretched exponential decay in the catalytic activity of single lipase B molecules
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