Point Mutations Effects on Charge Transport Properties of the Tumor-Suppressor Gene p53

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dc.creatorShih, Chi-Tin
dc.creatorRoche, Stephan
dc.creatorRömer, Rudolf A.
dc.date2007-08-23
dc.date.accessioned2026-07-07T08:53:08Z
dc.date.available2026-07-07T08:53:08Z
dc.descriptionWe report on a theoretical study of point mutations effects on charge transfer properties in the DNA sequence of the tumor-suppressor p53 gene. On the basis of effective single-strand or double-strand tight-binding models which simulate hole propagation along the DNA, a statistical analysis of charge transmission modulations associated with all possible point mutations is performed. We find that in contrast to non-cancerous mutations, mutation hotspots tend to result in significantly weaker {\em changes of transmission properties}. This suggests that charge transport could play a significant role for DNA-repairing deficiency yielding carcinogenesis.
dc.description4.1 PR style pages with 5 figures included
dc.identifierhttps://arxiv.org/abs/0708.3181
dc.identifierhttp://arxiv.org/abs/0708.3181
dc.identifierPhys. Rev. Lett. 100, 018105 (2008)
dc.identifierdoi:10.1103/PhysRevLett.100.018105
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/145516
dc.subjectGenomics
dc.subjectSoft Condensed Matter
dc.subjectQuantitative Methods
dc.titlePoint Mutations Effects on Charge Transport Properties of the Tumor-Suppressor Gene p53
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