Finding the center reliably: robust patterns of developmental gene expression
| dc.creator | Howard, Martin | |
| dc.creator | Wolde, Pieter Rein ten | |
| dc.date | 2005-11-10 | |
| dc.date.accessioned | 2026-07-07T06:52:33Z | |
| dc.date.available | 2026-07-07T06:52:33Z | |
| dc.description | We investigate a mechanism for the robust identification of the center of a developing biological system. We assume the existence of two morphogen gradients, an activator emanating from the anterior, and a co-repressor from the posterior. The co-repressor inhibits the action of the activator in switching on target genes. We apply this system to Drosophila embryos, where we predict the existence of a hitherto undetected posterior co-repressor. Using mathematical modelling, we show that a symmetric activator-co-repressor model can quantitatively explain the precise mid-embryo expression boundary of the hunchback gene, and the scaling of this pattern with embryo size. | |
| dc.description | 4 pages, 3 figures | |
| dc.identifier | https://arxiv.org/abs/q-bio/0511011 | |
| dc.identifier | http://arxiv.org/abs/q-bio/0511011 | |
| dc.identifier | Phys. Rev. Lett. 95, 208103 (2005) | |
| dc.identifier | doi:10.1103/PhysRevLett.95.208103 | |
| dc.identifier.uri | http://salesiana.dossiersoluciones.com/handle/123456789/105335 | |
| dc.subject | Tissues and Organs | |
| dc.subject | Other Condensed Matter | |
| dc.subject | Statistical Mechanics | |
| dc.subject | Other Quantitative Biology | |
| dc.title | Finding the center reliably: robust patterns of developmental gene expression | |
| dc.type | text |