Allosteric communication in Dihydrofolate Reductase: Signaling network and pathways for closed to occluded transition and back
| dc.creator | Chen, Jie | |
| dc.creator | Dima, Ruxandra I. | |
| dc.creator | Thirumalai, D. | |
| dc.date | 2007-08-15 | |
| dc.date.accessioned | 2026-07-07T08:23:46Z | |
| dc.date.available | 2026-07-07T08:23:46Z | |
| dc.description | E. Coli. dihydrofolate reductase (DHFR) undergoes conformational transitions between the closed (CS) and occluded (OS) states which, respectively, describe whether the active site is closed or occluded by the Met20 loop. A sequence-based approach is used to identify a network of residues that represents the allostery wiring diagram. We also use a self-organized polymer model to monitor the kinetics of the CS->OS and the reverse transitions. a sliding motion of Met20 loop is observed. The residues that facilitate the Met20 loop motion are part of the network of residues that transmit allosteric signals during the CS->OS transition. | |
| dc.description | 43 pages, 12 figures | |
| dc.identifier | https://arxiv.org/abs/0708.2083 | |
| dc.identifier | http://arxiv.org/abs/0708.2083 | |
| dc.identifier.uri | http://salesiana.dossiersoluciones.com/handle/123456789/136119 | |
| dc.subject | Biomolecules | |
| dc.title | Allosteric communication in Dihydrofolate Reductase: Signaling network and pathways for closed to occluded transition and back | |
| dc.type | text |