Comparison of amino acid occurrence and composition for predicting protein folds

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dc.creatorTaguchi, Y-h.
dc.creatorGromiha, M. Michael
dc.date2006-09-25
dc.date2007-05-10
dc.date.accessioned2026-07-07T08:00:33Z
dc.date.available2026-07-07T08:00:33Z
dc.descriptionBackground:Prediction of protein three-dimensional structures from amino acid sequences is a long-standing goal in computational/molecular biology. The successful discrimination of protein folds would help to improve the accuracy of protein 3D structure prediction. Results: In this work, we propose a method based on linear discriminant analysis (LDA) for recognizing proteins belonging to 30 different folds using the occurrence of amino acid residues in a set of 1612 proteins. The present method could discriminate the globular proteins from 30 major folding types with the sensitivity of 37%, which is comparable to or better than other methods in the literature. A web server has been developed for predicting the folding type of the protein from amino acid sequence and it is available at http://granular.com/PROLDA/. Conclusions:Linear discriminant analysis based on amino acid occurrence could successfully recognize protein folds. The present method has several advantages such as, (i) it directly predicts the folding type of a protein without performing pair-wise comparisons, (ii) it can discriminate folds among large number of proteins and (iii) it is very fast to obtain the results. This is a simple method, which can be easily incorporated in any other structure prediction algorithms.
dc.identifierhttps://arxiv.org/abs/q-bio/0609037
dc.identifierhttp://arxiv.org/abs/q-bio/0609037
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/128689
dc.subjectBiomolecules
dc.subjectSoft Condensed Matter
dc.subjectAdaptation and Self-Organizing Systems
dc.subjectQuantitative Methods
dc.titleComparison of amino acid occurrence and composition for predicting protein folds
dc.typetext

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