Breaking the VE-cadherin bonds

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dc.creatorGavard, Julie
dc.date2008-12-26
dc.date.accessioned2026-07-07T12:22:52Z
dc.date.available2026-07-07T12:22:52Z
dc.descriptionExchanges between the blood compartment and the surrounding tissues require a tight regulation by the endothelial barrier. Recent reports inferred that VE-cadherin, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. Indeed, a growing number of permeability inducing factors (PIFs) was shown to elicit signaling mechanisms culminating in VE-cadherin destabilization and global alteration of the junctional architecture. Conversely, anti-PIFs protect from VE-cadherin disruption and enhance cell cohesion. These findings provide evidence on how endothelial cell-cell junctions impact the vascular network, and change our perception about normal and aberrant angiogenesis.
dc.identifierhttps://arxiv.org/abs/0812.4707
dc.identifierhttp://arxiv.org/abs/0812.4707
dc.identifierFEBS Letters / FEBS-Letters; FEBS Microbiol Lett (2008) epub ahead of print
dc.identifierdoi:10.1016/j.febslet.2008.11.032
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/213798
dc.subjectCell Behavior
dc.titleBreaking the VE-cadherin bonds
dc.typetext

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