SAPHIR - a multi-scale, multi-resolution modeling environment targeting blood pressure regulation and fluid homeostasis

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dc.creatorThomas, S. Randall
dc.creatorAbdulhay, Enas
dc.creatorBaconnier, Pierre
dc.creatorFontecave, Julie
dc.creatorFrancoise, Jean-Pierre
dc.creatorGuillaud, Francois
dc.creatorHannaert, Patrick
dc.creatorHernandez, Alfredo
dc.creatorRolle, Virginie Le
dc.creatorMaziere, Pierre
dc.creatorTahi, Fariza
dc.creatorZehraoui, Farida
dc.date2008-06-12
dc.date.accessioned2026-07-07T12:19:29Z
dc.date.available2026-07-07T12:19:29Z
dc.descriptionWe present progress on a comprehensive, modular, interactive modeling environment centered on overall regulation of blood pressure and body fluid homeostasis. We call the project SAPHIR, for "a Systems Approach for PHysiological Integration of Renal, cardiac, and respiratory functions". The project uses state-of-the-art multi-scale simulation methods. The basic core model will give succinct input-output (reduced-dimension) descriptions of all relevant organ systems and regulatory processes, and it will be modular, multi-resolution, and extensible, in the sense that detailed submodules of any process(es) can be "plugged-in" to the basic model in order to explore, eg. system-level implications of local perturbations. The goal is to keep the basic core model compact enough to insure fast execution time (in view of eventual use in the clinic) and yet to allow elaborate detailed modules of target tissues or organs in order to focus on the problem area while maintaining the system-level regulatory compensations.
dc.identifierhttps://arxiv.org/abs/0806.2005
dc.identifierhttp://arxiv.org/abs/0806.2005
dc.identifierConference proceedings : Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 2007 (2007) 6649-52
dc.identifierdoi:10.1109/IEMBS.2007.4353884
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/212772
dc.subjectTissues and Organs
dc.titleSAPHIR - a multi-scale, multi-resolution modeling environment targeting blood pressure regulation and fluid homeostasis
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