Role of boundary constraints in DNA cyclization

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dc.creatorTkachenko, Alexei V.
dc.date2007-03-12
dc.date.accessioned2026-07-07T07:52:09Z
dc.date.available2026-07-07T07:52:09Z
dc.descriptionWe modify the classical Shimada-Yamakawa theory of DNA looping by generalizing the form of boundary constraints. This generalization is important in the context of DNA cyclization experiments since it mimics the reduced local rigidity of the "nicked" DNA loop. Our results indicate that the non-trivial boundary constraints may be responsible for the existing dramatic discrepancy between various DNA cyclization experiments. The developed effective Hamiltonian method may be further extended to a broad class of DNA looping problems.
dc.description4 pages, 3 figures
dc.identifierhttps://arxiv.org/abs/q-bio/0703026
dc.identifierhttp://arxiv.org/abs/q-bio/0703026
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/125777
dc.subjectBiomolecules
dc.subjectSoft Condensed Matter
dc.titleRole of boundary constraints in DNA cyclization
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