Transcriptional Regulation by the Numbers 2: Applications

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dc.creatorBintu, Lacramioara
dc.creatorBuchler, Nicolas E.
dc.creatorGarcia, Hernan G.
dc.creatorGerland, Ulrich
dc.creatorHwa, Terence
dc.creatorKondev, Jane'
dc.creatorKuhlman, Thomas
dc.creatorPhillips, Rob
dc.date2004-12-05
dc.date.accessioned2026-07-07T05:58:48Z
dc.date.available2026-07-07T05:58:48Z
dc.descriptionWith the increasing amount of experimental data on gene expression and regulation, there is a growing need for quantitative models to describe the data and relate them to the different contexts. The thermodynamic models reviewed in the preceding paper provide a useful framework for the quantitative analysis of bacterial transcription regulation. We review a number of well-characterized bacterial promoters that are regulated by one or two species of transcription factors, and apply the thermodynamic framework to these promoters. We show that the framework allows one to quantify vastly different forms of gene expression using a few parameters. As such, it provides a compact description useful for higher-level studies, e.g., of genetic networks, without the need to invoke the biochemical details of every component. Moreover, it can be used to generate hypotheses on the likely mechanisms of transcriptional control.
dc.description15 pages and 9 figures in PDF format
dc.identifierhttps://arxiv.org/abs/q-bio/0412011
dc.identifierhttp://arxiv.org/abs/q-bio/0412011
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/88493
dc.subjectMolecular Networks
dc.subjectQuantitative Methods
dc.titleTranscriptional Regulation by the Numbers 2: Applications
dc.typetext

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