Force spectroscopy on DNA by FM-AFM

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dc.creatorDi Santo, Giovanni
dc.creatorTobenas, Susana
dc.creatorAdamcik, Jozef
dc.creatorDietler, Giovanni
dc.date2007-12-10
dc.date.accessioned2026-07-07T08:48:14Z
dc.date.available2026-07-07T08:48:14Z
dc.descriptionWe present imaging and force spectroscopy measurements of DNA molecules adsorbed on functionalized mica. By means of Non-Contact mode AFM (NC-AFM) in Ultra High Vacuum (UHV), the frequency shift (Δf) versus separation (z) curves were measured providing a quantitative measurement of both force and energy of the tip-DNA interaction. Similarly, topographic images of the adsorbed DNA molecules in constant frequency shift mode were collected. The high resolution force measurements confirm the imaging contrast difference between the substrate and DNA. The force curves measured along the DNA molecule can be divided into two classes showing marked differences in the minimum of the interaction force and energy, indicating that NC-AFM could deliver chemical contrast along the DNA molecule.
dc.description3 pages, 2 figures, short communication under submission
dc.identifierhttps://arxiv.org/abs/0712.1424
dc.identifierhttp://arxiv.org/abs/0712.1424
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/143874
dc.subjectBiological Physics
dc.subjectGeneral Physics
dc.titleForce spectroscopy on DNA by FM-AFM
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