Epitope analysis for influenza vaccine design

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dc.creatorMunoz, Enrique T.
dc.creatorDeem, Michael W.
dc.date2004-08-23
dc.date.accessioned2026-07-07T05:58:36Z
dc.date.available2026-07-07T05:58:36Z
dc.descriptionUntil now, design of the annual influenza vaccine has relied on phylogenetic or whole-sequence comparisons of the viral coat proteins hemagglutinin and neuraminidase, with vaccine effectiveness assumed to correlate monotonically to the vaccine-influenza sequence difference. We use a theory from statistical mechanics to quantify the non-monotonic immune response that results from antigenic drift in the epitopes of the hemagglutinin and neuraminidase proteins. The results explain the ineffectiveness of the 2003--2004 influenza vaccine in the United States and provide an accurate measure by which to optimize the effectiveness of future annual influenza vaccines.
dc.description20 pages, 3 figures, to appear in Vaccine
dc.identifierhttps://arxiv.org/abs/q-bio/0408016
dc.identifierhttp://arxiv.org/abs/q-bio/0408016
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/88416
dc.subjectBiomolecules
dc.subjectQuantitative Methods
dc.titleEpitope analysis for influenza vaccine design
dc.typetext

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