Understanding conserved amino acids in proteins

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dc.creatorDokholyan, Nikolay V.
dc.creatorMirny, Leonid A.
dc.creatorShakhnovich, Eugene I.
dc.date2000-07-05
dc.date.accessioned2026-07-07T02:38:07Z
dc.date.available2026-07-07T02:38:07Z
dc.descriptionIt has been conjectured that evolution exerted pressure to preserve amino acids bearing thermodynamic, kinetic, and functional roles. In this letter we show that the physical requirement to maintain protein stability gives rise to a sequence conservatism pattern that is in remarkable agreement with that found in natural proteins. Based on the physical properties of amino acids, we propose a model of evolution that explains conserved amino acids across protein families sharing the same fold.
dc.description5 pages, 3 figures
dc.identifierhttps://arxiv.org/abs/cond-mat/0007084
dc.identifierhttp://arxiv.org/abs/cond-mat/0007084
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/16552
dc.subjectStatistical Mechanics
dc.subjectQuantitative Biology
dc.titleUnderstanding conserved amino acids in proteins
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