Impact of receptor-ligand distance on adhesion cluster stability

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dc.creatorErdmann, T.
dc.creatorSchwarz, U. S.
dc.date2006-12-18
dc.date2007-07-16
dc.date.accessioned2026-07-07T08:17:40Z
dc.date.available2026-07-07T08:17:40Z
dc.descriptionCells in multicellular organisms adhere to the extracellular matrix through two-dimensional clusters spanning a size range from very few to thousands of adhesion bonds. For many common receptor-ligand systems, the ligands are tethered to a surface via polymeric spacers with finite binding range, thus adhesion cluster stability crucially depends on receptor-ligand distance. We introduce a one-step master equation which incorporates the effect of cooperative binding through a finite number of polymeric ligand tethers. We also derive Fokker-Planck and mean field equations as continuum limits of the master equation. Polymers are modeled either as harmonic springs or as worm-like chains. In both cases, we find bistability between bound and unbound states for intermediate values of receptor-ligand distance and calculate the corresponding switching times. For small cluster sizes, stochastic effects destabilize the clusters at large separation, as shown by a detailed analysis of the stochastic potential resulting from the Fokker-Planck equation.
dc.descriptionfinal version after minor revisions
dc.identifierhttps://arxiv.org/abs/cond-mat/0612457
dc.identifierhttp://arxiv.org/abs/cond-mat/0612457
dc.identifierEur. Phys. J. E 22: 123-137 (2007)
dc.identifierdoi:10.1140/epje/e2007-00019-8
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/134170
dc.subjectSoft Condensed Matter
dc.subjectMaterials Science
dc.subjectSubcellular Processes
dc.titleImpact of receptor-ligand distance on adhesion cluster stability
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