Cooperativity of Protein Folding and the Random-Field Ising Model

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The relation between cooperativity of protein folding and the Random-Field Ising Model (RFIM) is established. Generalization of the Imry-Ma argument predicts cooperative folding transition for small heterogeneity of the interactions stabilizing the native structure. Monte Carlo simulation of a lattice model shows that starting from some finite heterogeneity folding transition is not cooperative and involves formation of domains.

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Condensed Matter, Quantitative Biology

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http://salesiana.dossiersoluciones.com/handle/123456789/27578

Consulte el texto completo en el siguiente enlace:

https://arxiv.org/abs/cond-mat/9606136
 http://arxiv.org/abs/cond-mat/9606136

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arXiv