Coherent motion of stereocilia assures the concerted gating of hair-cell transduction channels

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dc.creatorKozlov, Andrei S.
dc.creatorRisler, Thomas
dc.creatorHudspeth, A. J.
dc.date2009-02-16
dc.date.accessioned2026-07-07T12:42:19Z
dc.date.available2026-07-07T12:42:19Z
dc.descriptionThe hair cell's mechanoreceptive organelle, the hair bundle, is highly sensitive because its transduction channels open over a very narrow range of displacements. The synchronous gating of transduction channels also underlies the active hair-bundle motility that amplifies and tunes responsiveness. The extent to which the gating of independent transduction channels is coordinated depends on how tightly individual stereocilia are constrained to move as a unit. Using dual-beam interferometry in the bullfrog's sacculus, we found that thermal movements of stereocilia located as far apart as a bundle's opposite edges display high coherence and negligible phase lag. Because the mechanical degrees of freedom of stereocilia are strongly constrained, a force applied anywhere in the hair bundle deflects the structure as a unit. This feature assures the concerted gating of transduction channels that maximizes the sensitivity of mechanoelectrical transduction and enhances the hair bundle's capacity to amplify its inputs.
dc.description24 pages, including 6 figures, published in 2007
dc.identifierhttps://arxiv.org/abs/0902.2766
dc.identifierhttp://arxiv.org/abs/0902.2766
dc.identifierNature Neuroscience 10 (1), 87 - 92 (2007)
dc.identifierdoi:10.1038/nn1818
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/220038
dc.subjectSubcellular Processes
dc.subjectBiological Physics
dc.subjectQuantitative Methods
dc.titleCoherent motion of stereocilia assures the concerted gating of hair-cell transduction channels
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