ATR-FTIR spectroscopy detects alterations induced by organotin(IV) carboxylates in MCF-7 cells at sub-cytotoxic/-genotoxic concentrations

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dc.creatorAhmad, Muhammad S
dc.creatorMirza, Bushra
dc.creatorHussain, Mukhtiar
dc.creatorHanif, Muhammad
dc.creatorAli, Saqib
dc.creatorWalsh, Michael J
dc.creatorMartin, Francis L
dc.date2009-01-14
dc.date.accessioned2026-07-07T12:29:33Z
dc.date.available2026-07-07T12:29:33Z
dc.descriptionThe environmental impact of metal complexes such as organotin(IV) compounds is of increasing concern. Genotoxic effects of organotin(IV) compounds (0.01 microg/ml, 0.1 microg/ml or 1.0 microg/ml) were measured using the alkaline single-cell gel electrophoresis (comet) assay to measure DNA single-strand breaks (SSBs) and the cytokinesis-block micronucleus (CBMN) assay to determine micronucleus formation. Biochemical-cell signatures were also ascertained using attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy. In the comet assay, organotin(IV) carboxylates induced significantly-elevated levels of DNA SSBs. Elevated micronucleus-forming activities were also observed. Following interrogation using ATR-FTIR spectroscopy, infrared spectra in the biomolecular range (900 cm-1 - 1800 cm-1) derived from orga...
dc.description19 pages, 7 figures
dc.identifierhttps://arxiv.org/abs/0901.2039
dc.identifierhttp://arxiv.org/abs/0901.2039
dc.identifierPMC Biophysics 2008, 1:3
dc.identifierdoi:10.1186/1757-5036-1-3
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/215914
dc.subjectBiological Physics
dc.titleATR-FTIR spectroscopy detects alterations induced by organotin(IV) carboxylates in MCF-7 cells at sub-cytotoxic/-genotoxic concentrations
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