Bistability preserving model reduction in apoptosis
| dc.creator | Waldherr, Steffen | |
| dc.creator | Eissing, Thomas | |
| dc.creator | Chaves, Madalena | |
| dc.creator | Allgower, Frank | |
| dc.date | 2007-02-07 | |
| dc.date.accessioned | 2026-07-07T07:45:24Z | |
| dc.date.available | 2026-07-07T07:45:24Z | |
| dc.description | Biological systems are typically very complex and need to be reduced before they are amenable to a thorough analysis. Also, they often possess functionally important dynamic features like bistability. In model reduction, it is sometimes more desirable to preserve the dynamic features only than to recover a good quantitative approximation. We present an approach to reduce the order of a bistable dynamical system significantly while preserving bistability and the switching threshold. These properties are important for the operation of the system in the context of a larger network. As an application example, a bistable model for caspase activation in apoptosis is considered. | |
| dc.description | 6 pages, 5 figures | |
| dc.identifier | https://arxiv.org/abs/q-bio/0702011 | |
| dc.identifier | http://arxiv.org/abs/q-bio/0702011 | |
| dc.identifier.uri | http://salesiana.dossiersoluciones.com/handle/123456789/123519 | |
| dc.subject | Molecular Networks | |
| dc.title | Bistability preserving model reduction in apoptosis | |
| dc.type | text |