Single metallic nanoparticle imaging for protein detection in cells

Simple item page
dc.creatorCognet, Laurent
dc.creatorTardin, Catherine
dc.creatorBoyer, David
dc.creatorChoquet, Daniel
dc.creatorTamarat, Philippe
dc.creatorLounis, Brahim
dc.date2007-04-28
dc.date.accessioned2026-07-07T07:58:40Z
dc.date.available2026-07-07T07:58:40Z
dc.descriptionWe performed a visualization of membrane proteins labeled with 10-nm gold nanoparticles in cells, using an all-optical method based on photothermal interference contrast. The high sensitivity of the method and the stability of the signals allows 3D imaging of individual nanoparticles without the drawbacks of photobleaching and blinking inherent to fluorescent markers. A simple analytical model is derived to account for the measurements of the signal amplitude and the spatial resolution. The photothermal interference contrast method provides an efficient, reproducible, and promising way to visualize low amounts of proteins in cells by optical means.
dc.identifierhttps://arxiv.org/abs/0704.3816
dc.identifierhttp://arxiv.org/abs/0704.3816
dc.identifierProceeding of the national academy of sciences 100, 20 (30/09/2003) 11350
dc.identifierdoi:10.1073/pnas.1534635100
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/128093
dc.subjectOptics
dc.subjectBiological Physics
dc.titleSingle metallic nanoparticle imaging for protein detection in cells
dc.typetext

Files

Collections

arXiv