Intercellular Communication Via Intracellular Calcium Oscillations

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dc.creatorGracheva, M. E.
dc.creatorGunton, J. D.
dc.date2001-11-15
dc.date.accessioned2026-07-07T05:46:41Z
dc.date.available2026-07-07T05:46:41Z
dc.descriptionIn this letter we present the results of a simple model for intercellular communication via calcium oscillations, motivated in part by a recent experimental study. The model describes two cells (a "donor" and "sensor") whose intracellular dynamics involve a calcium-induced, calcium release process. The cells are coupled by assuming that the the input of the sensor cell is proportional to the output of the donor cell. As one varies the frequency of calcium oscillations of the donor cell, the sensor cell passes through a sequence of N:M phase locked regimes and exhibits a "Devil's staircase" behavior. Such a phase locked response has been seen experimentally in pulsatile stimulation of single cells. We also study a stochastic version of the coupled two cell model. We find that phase locking holds for realistic choices for the cell volume.
dc.description11 pages, 4 figures
dc.identifierhttps://arxiv.org/abs/physics/0111137
dc.identifierhttp://arxiv.org/abs/physics/0111137
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/84426
dc.subjectBiological Physics
dc.subjectQuantitative Biology
dc.titleIntercellular Communication Via Intracellular Calcium Oscillations
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