A trajectory approach to two-state kinetics of single particles on sculpted energy landscapes

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dc.creatorWu, David
dc.creatorGhosh, Kingshuk
dc.creatorInamdar, Mandar
dc.creatorLee, Heun Jin
dc.creatorFraser, Scott
dc.creatorDill, Ken
dc.creatorPhillips, Rob
dc.date2008-03-04
dc.date.accessioned2026-07-07T09:24:31Z
dc.date.available2026-07-07T09:24:31Z
dc.descriptionWe study the trajectories of a single colloidal particle as it hops between two energy wells A and B, which are sculpted using adjacent optical traps by controlling their respective power levels and separation. Whereas the dynamical behaviors of such systems are often treated by master-equation methods that focus on particles as actors, we analyze them here instead using a trajectory-based variational method called Maximum Caliber, which utilizes a dynamical partition function. We show that the Caliber strategy accurately predicts the full dynamics that we observe in the experiments: from the observed averages, it predicts second and third moments and covariances, with no free parameters. The covariances are the dynamical equivalents of Maxwell-like equilibrium reciprocal relations and Onsager-like dynamical relations. In short, this work describes an experimental model system for exploring full trajectory distributions in one-particle two-state systems, and it validates the Caliber approach as a useful way to understand trajectory-based dynamical distribution functions in this system.
dc.description4 pages, 4 figures, submitted to Physical Review Letters
dc.identifierhttps://arxiv.org/abs/0803.0360
dc.identifierhttp://arxiv.org/abs/0803.0360
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/156123
dc.subjectData Analysis, Statistics and Probability
dc.subjectBiological Physics
dc.titleA trajectory approach to two-state kinetics of single particles on sculpted energy landscapes
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