Recovery of Protein Structure from Contact Maps

Thumbnail Image

Date

Authors

Journal Title

Journal ISSN

Volume Title

Publisher

Abstract

Description

We present an efficient algorithm to recover the three dimensional structure of a protein from its contact map representation. First we show that when a physically realizable map is used as target, our method generates a structure whose contact map is essentially similar to the target. Furthermore, the reconstructed and original structures are similar up to the resolution of the contact map representation. Next we use non-physical target maps, obtained by corrupting a physical one; in this case our method essentially recovers the underlying physical map and structure. Hence our algorithm will help to fold proteins, using dynamics in the space of contact maps. Finally we investigate the manner in which the quality of the recovered structure degrades when the number of contacts is reduced.
27 pages, RevTex, 12 figures included

Keywords

Soft Condensed Matter, Quantitative Biology

Citation

URI

http://salesiana.dossiersoluciones.com/handle/123456789/151797

Consulte el texto completo en el siguiente enlace:

https://arxiv.org/abs/cond-mat/9705211
 http://arxiv.org/abs/cond-mat/9705211

Collections

arXiv