Evolution at the Edge of Chaos: A Paradigm for the Maturation of the Humoral Immune Response

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dc.creatorTheodosopoulos, Patricia
dc.creatorTheodosopoulos, Ted
dc.date2004-06-06
dc.date.accessioned2026-07-07T05:58:28Z
dc.date.available2026-07-07T05:58:28Z
dc.descriptionWe study the maturation of the antibody population following primary antigen presentation as a global optimization problem. Emphasis is placed on the trade-off between the safety of mutations that lead to local improvements to the antibody's affinity and the necessity of eventual mutations that result in global reconfigurations in the antibody's shape. The model described herein gives evidence of the underlying optimization process from which the rapidity and consistency of the biologic response could be derived.
dc.description26 pages, 8 figures, presented at the DIMACS Workshop on Evolution as Computation, 1998
dc.identifierhttps://arxiv.org/abs/q-bio/0406014
dc.identifierhttp://arxiv.org/abs/q-bio/0406014
dc.identifierEvolution as Computation, Springer Natural Computing Series, Landweber and Winfree eds., 2002, pp. 41-66
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/88368
dc.subjectQuantitative Methods
dc.subjectPopulations and Evolution
dc.titleEvolution at the Edge of Chaos: A Paradigm for the Maturation of the Humoral Immune Response
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