A phenomenological approach to the simulation of metabolism and proliferation dynamics of large tumour cell populations

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dc.creatorChignola, Roberto
dc.creatorMilotti, Edoardo
dc.date2005-10-12
dc.date.accessioned2026-07-07T06:48:25Z
dc.date.available2026-07-07T06:48:25Z
dc.descriptionA major goal of modern computational biology is to simulate the collective behaviour of large cell populations starting from the intricate web of molecular interactions occurring at the microscopic level. In this paper we describe a simplified model of cell metabolism, growth and proliferation, suitable for inclusion in a multicell simulator, now under development (Chignola R and Milotti E 2004 Physica A 338 261-6). Nutrients regulate the proliferation dynamics of tumor cells which adapt their behaviour to respond to changes in the biochemical composition of the environment. This modeling of nutrient metabolism and cell cycle at a mesoscopic scale level leads to a continuous flow of information between the two disparate spatiotemporal scales of molecular and cellular dynamics that can be simulated with modern computers and tested experimentally.
dc.description58 pages, 7 figures, 3 tables, pdf only
dc.identifierhttps://arxiv.org/abs/physics/0510110
dc.identifierhttp://arxiv.org/abs/physics/0510110
dc.identifierPhysical Biology, 2 (2005) 8-22
dc.identifierdoi:10.1088/1478-3967/2/1/002
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/103994
dc.subjectBiological Physics
dc.titleA phenomenological approach to the simulation of metabolism and proliferation dynamics of large tumour cell populations
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