Forcing reversibility in the no strand-bias substitution model allows for the theoretical and practical identifiability of its 5 parameters from pairwise DNA sequence comparisons
| dc.creator | Zagordi, O. | |
| dc.creator | Lobry, J. R. | |
| dc.date | 2004-12-15 | |
| dc.date | 2004-12-16 | |
| dc.date.accessioned | 2026-07-07T05:58:49Z | |
| dc.date.available | 2026-07-07T05:58:49Z | |
| dc.description | Because of the base pairing rules in DNA, some mutations experienced by a portion of DNA during its evolution result in the same substitution, as we can only observe differences in coupled nucleotides. Then, in the absence of a bias between the two DNA strands, a model with at most 6 different parameters instead of 12 is sufficient to study the evolutionary relationship between homologous sequences derived from a common ancestor. On the other hand the same symmetry reduces the number of independent observations which can be made. Such a reduction can in some cases invalidate the calculation of the parameters. A compromise between biologically acceptable hypotheses and tractability is introduced and a five parameter reversible no-strand-bias condition (RNSB) is presented. The identifiability of the parameters under this model is shown by examples. | |
| dc.description | 12 pages, 4 figures, corrected typos | |
| dc.identifier | https://arxiv.org/abs/q-bio/0412028 | |
| dc.identifier | http://arxiv.org/abs/q-bio/0412028 | |
| dc.identifier | Gene, Volume 347 (2) 175-182 (2005) | |
| dc.identifier | doi:10.1016/j.gene.2004.12.019 | |
| dc.identifier.uri | http://salesiana.dossiersoluciones.com/handle/123456789/88504 | |
| dc.subject | Populations and Evolution | |
| dc.title | Forcing reversibility in the no strand-bias substitution model allows for the theoretical and practical identifiability of its 5 parameters from pairwise DNA sequence comparisons | |
| dc.type | text |