Genetically engineered cardiac pacemaker: stem cells transfected with HCN2 gene and myocytes - a model

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dc.creatorKanani, Sandra
dc.creatorPumir, Alain
dc.creatorKrinsky, Valentine
dc.date2005-11-14
dc.date2005-11-16
dc.date.accessioned2026-07-07T06:52:33Z
dc.date.available2026-07-07T06:52:33Z
dc.descriptionArtificial biological pacemakers were developed and tested in canine ventricles. Next steps will require obtaining oscillations sensitive to external regulations, and robust with respect to long term drifts of expression levels of pacemaker currents and gap junctions. We introduce mathematical models intended to be used in parallel with the experiments. The models describe human mesenchymal stem cells ({\it hMSC}) transfected with HCN2 genes and connected to myocytes. They are intended to mimic experiments with oscillation induction in a cell pair, in cell culture and in the cardiac tissue. We give examples of oscillations in a cell pair, in a 1 dim cell culture, and oscillation dependence on number of pacemaker channels per cell and number of gap junctions. The models permit to mimic experiments with levels of gene expressions not achieved yet, and to predict if the work to achieve this levels will significantly increase the quality of oscillations. This give arguments for selecting the directions of the experimental work.
dc.identifierhttps://arxiv.org/abs/q-bio/0511015
dc.identifierhttp://arxiv.org/abs/q-bio/0511015
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/105338
dc.subjectCell Behavior
dc.titleGenetically engineered cardiac pacemaker: stem cells transfected with HCN2 gene and myocytes - a model
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