Dynamics of gene expression under feedback

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dc.creatorPulkkinen, Otto
dc.creatorBerg, Johannes
dc.date2008-07-22
dc.date.accessioned2026-07-07T09:52:08Z
dc.date.available2026-07-07T09:52:08Z
dc.descriptionGene expression is a stochastic process governed by the presence of specific transcription factors. Here we study the dynamics of gene expression in the presence of feedback, where a gene regulates its own expression. The nonlinear coupling between input and output of gene expression can generate a dynamics different from simple scenarios such as the Poisson process. This is exemplified by our findings for the time intervals over which genes are transcriptionally active and inactive. We apply our results to the lac system in E. coli, where parametric inference on experimental data results in a broad distribution of gene activity intervals.
dc.identifierhttps://arxiv.org/abs/0807.3521
dc.identifierhttp://arxiv.org/abs/0807.3521
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/165486
dc.subjectCell Behavior
dc.subjectStatistical Mechanics
dc.titleDynamics of gene expression under feedback
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