A Deterministic Approach to the Protein Design Problem

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dc.creatorSkorobogatiy, Maksim
dc.creatorGuo, Hong
dc.creatorZuckermann, Martin J.
dc.date1998-03-26
dc.date.accessioned2026-07-07T03:10:13Z
dc.date.available2026-07-07T03:10:13Z
dc.descriptionWe have considered the problem of protein design based on a model where the contact energy between amino acid residues is fitted phenomenologically using the Miyazawa--Jernigan matrix. Due to the simple form of the contact energy function, an analytical prescription is found which allows us to design energetically stable sequences for fixed amino acid residues compositions and target structures. The theoretically obtained sequences are compared with real proteins and good correspondence is obtained. Finally we discuss the effect of discrepancies in the procedure used to fit the contact energy on our theoretical predictions.
dc.description15 pages, 4 figures
dc.identifierhttps://arxiv.org/abs/cond-mat/9803323
dc.identifierhttp://arxiv.org/abs/cond-mat/9803323
dc.identifierMaxim Skorobogatiy, Hong Guo, Martin Zuckerman, Macromolecules, vol. 30(11), pp. 3403-3410, (1997)
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/28170
dc.subjectSoft Condensed Matter
dc.subjectQuantitative Biology
dc.titleA Deterministic Approach to the Protein Design Problem
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