Computer Simulations Reveal Motor Properties generating stable anti-parallel Microtubule interactions

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dc.creatorNedelec, Francois
dc.date2002-09-30
dc.date.accessioned2026-07-07T02:47:30Z
dc.date.available2026-07-07T02:47:30Z
dc.descriptionAn aster of microtubules is a set of flexible polar filaments with dynamic plus-ends, which irradiate from a common location at which the minus ends of the filaments are found. Processive soluble oligomeric motor complexes can bind simultaneously to two microtubules, and thus exert forces between two asters. Using computer simulations, I have explored systematically the possible steady-state regimes reached by two asters under the action of various kinds of oligomeric motors. As expected, motor complexes can induce the asters to fuse, for example when the complexes consist only of minus-end directed motors, or to fully separate, when the motors are plus-end directed. More surprisingly, complexes made of two motors of opposite directionalities can also lead to anti-parallel interactions between overlapping microtubules that are stable and sustained, like those seen in mitotic spindle structures. This suggests that such hetero-complexes could have significant biological role, if they exist in the cell.
dc.description26 pages, The final formated version can be downloaded at www.jcb.org
dc.identifierhttps://arxiv.org/abs/cond-mat/0209678
dc.identifierhttp://arxiv.org/abs/cond-mat/0209678
dc.identifierThe Journal of Cell Biology, Volume 158, Number 6, September 16, 2002 1005-1015
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/20033
dc.subjectSoft Condensed Matter
dc.subjectCell Behavior
dc.titleComputer Simulations Reveal Motor Properties generating stable anti-parallel Microtubule interactions
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