Directionality is an inherent property of biochemical networks
| dc.creator | Yang, Feng | |
| dc.creator | Qi, Feng | |
| dc.creator | Beard, Daniel A. | |
| dc.date | 2007-01-02 | |
| dc.date | 2007-02-01 | |
| dc.date.accessioned | 2026-07-07T07:44:07Z | |
| dc.date.available | 2026-07-07T07:44:07Z | |
| dc.description | Thermodynamic constraints on reactions directions are inherent in the structure of a given biochemical network. However, concrete procedures for determining feasible reaction directions for large-scale metabolic networks are not well established. This work introduces a systematic approach to compute reaction directions, which are constrained by mass balance and thermodynamics, for genome-scale networks. In addition, it is shown that the nonconvex solution space constrained by physicochemical constraints can be approximated by a set of linearized subspaces in which mass and thermodynamic balance are guaranteed. The developed methodology can be used to {\it ab initio} predict reaction directions of genome-scale networks based solely on the network stoichoimetry. | |
| dc.description | A short version of the previous one, more concise and previse. It includes 5 pages, 5 figures and 1 table | |
| dc.identifier | https://arxiv.org/abs/q-bio/0701004 | |
| dc.identifier | http://arxiv.org/abs/q-bio/0701004 | |
| dc.identifier.uri | http://salesiana.dossiersoluciones.com/handle/123456789/123080 | |
| dc.subject | Molecular Networks | |
| dc.title | Directionality is an inherent property of biochemical networks | |
| dc.type | text |