The Alternative Choice of Constitutive Exons throughout Evolution

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dc.creatorLev-Maor, Galit
dc.creatorGoren, Amir
dc.creatorSela, Noa
dc.creatorKim, Eddo
dc.creatorKeren, Hadas
dc.creatorDoron-Faigenboim, Adi
dc.creatorLeibman-Barak, Shelly
dc.creatorPupko, Tal
dc.creatorAst, Gil
dc.date2008-11-21
dc.date.accessioned2026-07-07T10:20:05Z
dc.date.available2026-07-07T10:20:05Z
dc.descriptionAlternative cassette exons are known to originate from two processes exonization of intronic sequences and exon shuffling. Herein, we suggest an additional mechanism by which constitutively spliced exons become alternative cassette exons during evolution. We compiled a dataset of orthologous exons from human and mouse that are constitutively spliced in one species but alternatively spliced in the other. Examination of these exons suggests that the common ancestors were constitutively spliced. We show that relaxation of the 59 splice site during evolution is one of the molecular mechanisms by which exons shift from constitutive to alternative splicing. This shift is associated with the fixation of exonic splicing regulatory sequences (ESRs) that are essential for exon definition and control the inclusion level only after the transition to alternative splicing. The effect of each ESR on splicing and the combinatorial effects between two ESRs are conserved from fish to human. Our results uncover an evolutionary pathway that increases transcriptome diversity by shifting exons from constitutive to alternative splicing
dc.identifierhttps://arxiv.org/abs/0811.3514
dc.identifierhttp://arxiv.org/abs/0811.3514
dc.identifierPLoS Genet 2007 3(11): e203
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/174740
dc.subjectGenomics
dc.subjectPopulations and Evolution
dc.titleThe Alternative Choice of Constitutive Exons throughout Evolution
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