Can repulsion be induced by attraction: a role of ephrin-B1 in retinotectal mapping?

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dc.creatorTsigankov, Dmitry N.
dc.creatorKoulakov, Alexei A.
dc.date2004-03-11
dc.date.accessioned2026-07-07T05:58:17Z
dc.date.available2026-07-07T05:58:17Z
dc.descriptionWe study a role of EphB receptors and their ligand ephrin-B1 in dorsal-ventral retinotopic mapping. Earlier studies suggested that ephrin-B1 acts as an attractant for EphB expressing axons. We address the results of the recent experiment in chick tectum (McLaughlin et al., 2003b) in which axons of retinal ganglion cells were shown to be repelled by high ephrin-B1 density. Thus it was proposed that ephrin-B1 might act as both attractant and repellent. We show that the same axonal behavior may follow from attraction to ephrin-B1 density and axonal competition for space. Therefore, we show how apparent repulsive interaction can be induced by a combination of attraction to the target and competitive interactions between axons. We suggest an experimental test that may distinguish repulsive interaction with the target from repulsion induced by attraction and competition.
dc.description4 pages
dc.identifierhttps://arxiv.org/abs/q-bio/0403013
dc.identifierhttp://arxiv.org/abs/q-bio/0403013
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/88302
dc.subjectNeurons and Cognition
dc.subjectQuantitative Methods
dc.titleCan repulsion be induced by attraction: a role of ephrin-B1 in retinotectal mapping?
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