Conserved network motifs allow protein-protein interaction prediction
| dc.creator | Albert, Istvan | |
| dc.creator | Albert, Reka | |
| dc.date | 2004-06-22 | |
| dc.date.accessioned | 2026-07-07T05:58:31Z | |
| dc.date.available | 2026-07-07T05:58:31Z | |
| dc.description | High-throughput protein interaction detection methods are strongly affected by false positive and false negative results. Focused experiments are needed to complement the large-scale methods by validating previously detected interactions but it is often difficult to decide which proteins to probe as interaction partners. Developing reliable computational methods assisting this decision process is a pressing need in bioinformatics. We show that we can use the conserved properties of the protein network to identify and validate interaction candidates. We apply a number of machine learning algorithms to the protein connectivity information and achieve a surprisingly good overall performance in predicting interacting proteins. Using a 'leave-one-out' approach we find average success rates between 20-50% for predicting the correct interaction partner of a protein. We demonstrate that the success of these methods is based on the presence of conserved interaction motifs within the network. A reference implementation and a table with candidate interacting partners for each yeast protein are available at http://www.protsuggest.org | |
| dc.identifier | https://arxiv.org/abs/q-bio/0406042 | |
| dc.identifier | http://arxiv.org/abs/q-bio/0406042 | |
| dc.identifier.uri | http://salesiana.dossiersoluciones.com/handle/123456789/88384 | |
| dc.subject | Molecular Networks | |
| dc.subject | Genomics | |
| dc.title | Conserved network motifs allow protein-protein interaction prediction | |
| dc.type | text |