Bimodality, prion aggregates infectivity and prediction of strain phenomenon

Simple item page
dc.creatorCalvez, Vincent
dc.creatorLenuzza, Natacha
dc.creatorOelz, Dietmar
dc.creatorDeslys, Jean-Philippe
dc.creatorLaurent, Pascal
dc.creatorMouthon, Franck
dc.creatorPerthame, Benoît
dc.date2008-02-14
dc.date.accessioned2026-07-07T09:20:47Z
dc.date.available2026-07-07T09:20:47Z
dc.descriptionWe consider a model for the polymerization (fragmentation) process involved in infectious prion self-replication and study both its dynamics and non-zero steady state. We address several issues. Firstly, we give conditions leading to size repartitions of PrPsc aggregates that exhibit bimodal distributions, as indicated by recent experimental studies of prion aggregates distribution. Secondly, we show stability results for this steady state for general coefficients where reduction to a system of differential equations is not possible. We use a duality method based on recent ideas developed for population models. These results underline the potential influence of the amyloid precursor production rate in promoting amyloidogenic diseases. Finally, we numerically investigate the influence of different parameters of the model on PrPsc accumulation kinetics, in the aim to study specific features of prion strains.
dc.description21 pages
dc.identifierhttps://arxiv.org/abs/0802.2024
dc.identifierhttp://arxiv.org/abs/0802.2024
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/154832
dc.subjectAnalysis of PDEs
dc.titleBimodality, prion aggregates infectivity and prediction of strain phenomenon
dc.typetext

Files

Collections

arXiv