Bayesian Method for Disease QTL Detection and Mapping, using a Case and Control Design and DNA Pooling
| dc.creator | Johnson, Toby | |
| dc.date | 2005-07-13 | |
| dc.date.accessioned | 2026-07-07T09:22:09Z | |
| dc.date.available | 2026-07-07T09:22:09Z | |
| dc.description | This paper describes a Bayesian statistical method for determining the genetic basis of a complex genetic trait. The method uses a sample of unrelated individuals classified into two groups, for example cases and controls. Each group is assumed to have been genotyped at a battery of marker loci using a laboratory effort efficient technique called DNA pooling. The aim is to detect and map a quantitative trait locus (QTL) that is not one of the typed markers. The method works by conducting an exact Bayesian analysis under a number of simplifying population genetic assumptions that are somewhat unrealistic. Despite this, the method is shown to perform acceptably on datasets simulated under a more realistic model, and furthermore is shown to outperform classical single point methods. | |
| dc.identifier | https://arxiv.org/abs/q-bio/0507018 | |
| dc.identifier | http://arxiv.org/abs/q-bio/0507018 | |
| dc.identifier | Biostatistics (2007) 8:546--565 | |
| dc.identifier | doi:10.1093/biostatistics/kxl028 | |
| dc.identifier.uri | http://salesiana.dossiersoluciones.com/handle/123456789/155277 | |
| dc.subject | Genomics | |
| dc.subject | Populations and Evolution | |
| dc.subject | Quantitative Methods | |
| dc.title | Bayesian Method for Disease QTL Detection and Mapping, using a Case and Control Design and DNA Pooling | |
| dc.type | text |