Two computational regimes of a single-compartment neuron separated by a planar boundary in conductance space

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dc.creatorLundstrom, Brian Nils
dc.creatorHong, Sungho
dc.creatorHiggs, Matthew H.
dc.creatorFairhall, Adrienne L.
dc.date2007-05-29
dc.date2007-07-16
dc.date.accessioned2026-07-07T08:17:27Z
dc.date.available2026-07-07T08:17:27Z
dc.descriptionRecent in vitro data show that neurons respond to input variance with varying sensitivities. Here, we demonstrate that Hodgkin-Huxley (HH) neurons can operate in two computational regimes, one that is more sensitive to input variance (differentiating) and one that is less sensitive (integrating). A boundary plane in the 3D conductance space separates these two regimes. For a reduced HH model, this plane can be derived analytically from the V nullcline, thus suggesting a means of relating biophysical parameters to neural computation by analyzing the neuron's dynamical system.
dc.description18 pages, 5 figures, accepted version
dc.identifierhttps://arxiv.org/abs/0705.4316
dc.identifierhttp://arxiv.org/abs/0705.4316
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/134098
dc.subjectNeurons and Cognition
dc.subjectBiological Physics
dc.titleTwo computational regimes of a single-compartment neuron separated by a planar boundary in conductance space
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