Nonlinear Relaxation Dynamics in Elastic Networks and Design Principles of Molecular Machines

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dc.creatorTogashi, Yuichi
dc.creatorMikhailov, Alexander S.
dc.date2007-05-17
dc.date.accessioned2026-07-07T08:09:18Z
dc.date.available2026-07-07T08:09:18Z
dc.descriptionAnalyzing nonlinear conformational relaxation dynamics in elastic networks corresponding to two classical motor proteins, we find that they respond by well-defined internal mechanical motions to various initial deformations and that these motions are robust against external perturbations. We show that this behavior is not characteristic for random elastic networks. However, special network architectures with such properties can be designed by evolutionary optimization methods. Using them, an example of an artificial elastic network, operating as a cyclic machine powered by ligand binding, is constructed.
dc.description12 pages, 9 figures
dc.identifierhttps://arxiv.org/abs/0705.2504
dc.identifierhttp://arxiv.org/abs/0705.2504
dc.identifierProc. Natl. Acad. Sci. (USA) 104, 8697 (2007)
dc.identifierdoi:10.1073/pnas.0702950104
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/131501
dc.subjectBiomolecules
dc.subjectSoft Condensed Matter
dc.subjectChemical Physics
dc.titleNonlinear Relaxation Dynamics in Elastic Networks and Design Principles of Molecular Machines
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