A Physical Model for the Condensation and Decondensation of Eukaryotic Chromosomes

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dc.creatorMozziconacci, Julien
dc.creatorLavelle, Christophe
dc.creatorBarbi, Maria
dc.creatorLesne, Annick
dc.creatorVictor, Jean-Marc
dc.date2005-12-12
dc.date2007-09-03
dc.date.accessioned2026-07-07T08:27:02Z
dc.date.available2026-07-07T08:27:02Z
dc.descriptionDuring the eukaryotic cell cycle, chromatin undergoes several conformational changes, which are believed to play key roles in gene expression regulation during interphase, and in genome replication and division during mitosis. In this paper, we propose a scenario for chromatin structural reorganization during mitosis, which bridges all the different scales involved in chromatin architecture, from nucleosomes to chromatin loops. We build a model for chromatin, based on available data, taking into account both physical and topological constraints DNA has to deal with. Our results suggest that the mitotic chromosome condensation/decondensation process is induced by a structural change at the level of the nucleosome itself.
dc.identifierhttps://arxiv.org/abs/q-bio/0512027
dc.identifierhttp://arxiv.org/abs/q-bio/0512027
dc.identifierFEBS Letters 580 (2006) 368-372
dc.identifierdoi:10.1016/j.febslet.2005.12.053
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/137145
dc.subjectSubcellular Processes
dc.titleA Physical Model for the Condensation and Decondensation of Eukaryotic Chromosomes
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