Analysis of PIN1 WW domain through a simple Statistical Mechanics Model

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dc.creatorBruscolini, Pierpaolo
dc.creatorCecconi, Fabio
dc.date2005-01-11
dc.date.accessioned2026-07-07T05:53:55Z
dc.date.available2026-07-07T05:53:55Z
dc.descriptionWe have applied a simple statistical-mechanics G$\bar{\text{o}}$-like model to the analysis of the PIN1 WW domain, resorting to Mean Field and Monte Carlo techniques to characterize its thermodynamics, and comparing the results with the wealth of available experimental data. PIN1 WW domain is a 39-residues protein fragment which folds on an antiparallel $β$-sheet, thus representing an interesting model system to study the behavior of these secondary structure elements. Results show that the model correctly reproduces the two-state behavior of the protein, and also the trends of the experimental $ϕ_T$-values. Moreover, there is a good agreement between Monte Carlo results and the Mean-Field ones, which can be obtained with a substantially smaller computational effort.
dc.descriptionRevTex4: 6 pages, 6 eps-figures
dc.identifierhttps://arxiv.org/abs/physics/0501055
dc.identifierhttp://arxiv.org/abs/physics/0501055
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/86802
dc.subjectBiological Physics
dc.subjectSoft Condensed Matter
dc.titleAnalysis of PIN1 WW domain through a simple Statistical Mechanics Model
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