2026-07-072026-07-07http://salesiana.dossiersoluciones.com/handle/123456789/167964Prediction and control of cancer invasion is a vital problem in medical science. This paper proposes a modern geometric Ricci-flow and entropy based model for control of avascular multicellular tumor spheroid growth and decay. As a tumor growth/decay control tool, a monoclonal antibody therapy is proposed. Keywords: avascular tumor growth and decay, multicellular tumor spheroid, Ricci flow and entropy, nonlinear heat equation, monoclonal antibody cancer therapy24 pages, 2 figures, Latex, revisedCell BehaviorPopulations and Evolutiontext