2026-07-072026-07-07http://salesiana.dossiersoluciones.com/handle/123456789/150The mechanism of suberoylanilide hydroxamic acid in cell growth inhibition involved induction of pRb-2/p130 interaction and nuclear translocation with E2F-4, followed by significant repression in E2F-1 and PCNA nuclear levels, which led to inhibition in DNA synthesis in mammary epithelial cell lines.Copyright © 2000 BioMed Central Ltd on behalf of the copyright holderPrimary ResearchText