2026-07-072026-07-07http://salesiana.dossiersoluciones.com/handle/123456789/215867We derive a fluctuation theorem for generalized work distributions, related to bijective mappings of the phase spaces of two physical systems, and use it to derive a two-sided constraint maximum likelihood estimator of their free energy difference which uses samples from the equilibrium configurations of both systems. As an application, we evaluate the chemical potential of a dense Lennard-Jones fluid and study the construction and performance of suitable maps.17 pages, 11 figuresStatistical Mechanicstext