2026-07-072026-07-07http://salesiana.dossiersoluciones.com/handle/123456789/144922The genetic code markup is the assignment of stop codons. The standard genetic code markup ensures the maximum possible stability of genetic information with respect to two fault classes: frameshift and nonsense mutations. There are only 528 (about 1,3% of total number) optimal markups in the set of markups having 3 stop codons. Among the sets of markups with 1,2,...,8 stop codons, the standard case having 3 stop codons has maximum absolute number of optimal markups.16 pages, 5 figures, 2 tablesPopulations and EvolutionOn the optimality of the standard genetic code: the role of stop codonstext