2026-07-072026-07-07http://salesiana.dossiersoluciones.com/handle/123456789/216612To regulate a particular gene, a transcription factor (TF) needs to bind a specific genome location. How is this genome address specified amid the presence of ~10^6-10^9 decoy sites? Our analysis of 319 known TF binding motifs clearly demonstrates that prokaryotes and eukaryotes use strikingly different strategies to target TFs to specific genome locations; eukaryotic TFs exhibit widespread nonfunctional binding and require clustering of sites in regulatory regions for specificity.4 pages, 2 figures, expanded Supplementary Methods, Figures and TablesGenomicsBiomoleculesMolecular NetworksPopulations and EvolutionQuantitative MethodsSubcellular Processestext