2026-07-072026-07-07http://salesiana.dossiersoluciones.com/handle/123456789/107270The contribution of axial anomaly to charge symmetry breaking in pion-nucleon coupling constants is calculated within instanton model for QCD vacuum. It has been demonstrated that the contribution is large and allows to explain Nolen-Schiffer anomaly.4 pages. Contribution to "Sense of Beauty in Physics - a volume in honour of Adriano Di Giacomo" (Pisa University Press, Pisa, 2006), on the occasion of his 70th birthdayHigh Energy Physics - PhenomenologyNuclear ExperimentNuclear Theorytext