2026-07-072026-07-07http://salesiana.dossiersoluciones.com/handle/123456789/212594One of Pranab K. Sen's major research areas is sequential nonparametrics and semiparametrics and their applications to clinical trials, to which he has made many important contributions. Herein we review a number of these contributions and related developments. We also describe some recent work on nonparametric and semiparametric inference and the associated computational methods in time-sequential clinical trials with survival endpoints.Published in at http://dx.doi.org/10.1214/193940307000000257 the IMS Collections (http://www.imstat.org/publications/imscollections.htm) by the Institute of Mathematical Statistics (http://www.imstat.org)Statistics Theory62L10, 62G10 (Primary) 62N02 (Secondary)text