2026-07-072026-07-07http://salesiana.dossiersoluciones.com/handle/123456789/138507Simple theoretical concepts and models have been helpful to understand the folding rates and routes of single-domain proteins. As reviewed in this article, a physical principle that appears to underly these models is loop closure.27 pages, 5 figures; to appear in Archives of Biochemistry and BiophysicsBiomoleculestext