2026-07-072026-07-07http://salesiana.dossiersoluciones.com/handle/123456789/180072Endothelial barrier function requires the adhesive activity of VE-cadherin and claudin-5, which are key components of adherens and tight endothelial junctions, respectively. Emerging evidence suggests that VE-cadherin controls claudin-5 expression by preventing the nuclear accumulation of FoxO1 and -catenin, which repress the claudin-5 promoter. This indicates that a crosstalk mechanism operates between these junctional structures.Cell BehaviorVE-cadherin and claudin-5: it takes two to tangotext