Cooperativity of Protein Folding and the Random-Field Ising Model

2026-07-072026-07-07http://salesiana.dossiersoluciones.com/handle/123456789/27578The relation between cooperativity of protein folding and the Random-Field Ising Model (RFIM) is established. Generalization of the Imry-Ma argument predicts cooperative folding transition for small heterogeneity of the interactions stabilizing the native structure. Monte Carlo simulation of a lattice model shows that starting from some finite heterogeneity folding transition is not cooperative and involves formation of domains.Condensed MatterQuantitative BiologyCooperativity of Protein Folding and the Random-Field Ising Modeltext