2026-07-072026-07-07http://salesiana.dossiersoluciones.com/handle/123456789/134098Recent in vitro data show that neurons respond to input variance with varying sensitivities. Here, we demonstrate that Hodgkin-Huxley (HH) neurons can operate in two computational regimes, one that is more sensitive to input variance (differentiating) and one that is less sensitive (integrating). A boundary plane in the 3D conductance space separates these two regimes. For a reduced HH model, this plane can be derived analytically from the V nullcline, thus suggesting a means of relating biophysical parameters to neural computation by analyzing the neuron's dynamical system.18 pages, 5 figures, accepted versionNeurons and CognitionBiological Physicstext