Enhancing protein drop stability for crystallization by chemical patterning

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Motion of protein drops on crystallization media during routine handling is a major factor affecting the reproducibility of crystallization conditions. Drop stability can be enhanced by chemical patterning to more effectively pin the drop's contact line. As an example, a hydrophilic area is patterned on an initially flat hydrophobic glass slide. The drop remains confined to the hydrophilic area, and the maximum drop size that remains stable when the slide is rotated to the vertical position increases. This simple method is readily scalable and has the potential to significantly improve outcomes in hanging and sitting drop crystallization.
text 4 pages, 6 jpg figures

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Soft Condensed Matter, Materials Science

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http://salesiana.dossiersoluciones.com/handle/123456789/109682

Consulte el texto completo en el siguiente enlace:

https://arxiv.org/abs/cond-mat/0604326
 http://arxiv.org/abs/cond-mat/0604326
 Acta Crystallographica Section D (2005) 61, 1563
 doi:10.1107/S0907444905028866

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arXiv